Research Assistant

Department of Physics

Northeastern University

Boston, MA 02115

USA.

 

Thayaparan Paramanathan

My research is a component at Williams lab at Northeastern University. I am interested in studying Drug-DNA interactions at single molecule level using optical tweezers.

In our recent studies with binuclear ruthenium complexes, by mechanically manipulating the DNA molecule we came across with very interesting results right away, proving experimentally for the first time that these complexes require at least one base pair to be melted to thread through the DNA bases. (published in JACS).  Studies with ActinomycinD a drug used in cancer treatment and a potential HIV drug have yield multiple binding modes with interesting kinetics (soon to be published).

 

E-mail: t.paramanathan@neu.edu

Phone: 617-373-3677

Office: Egan 331

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