MRSEC Postdoctoral Associate

Department of Biochemistry & Biophysics

Brandeis University

415 South Street

Waltham, MA  02454

USA

THAYAPARAN PARAMANATHAN

My current research funded by MRSEC is a component of the Prof. Jeff Gelles’s lab at Brandeis University. We are interested  in studying the dissociation pathway of small ligands in the presence of competitors and explore how rapid rebinding affects the dissociation rates in biological systems. This project is a collaboration with Prof. Jane Kondev attached to the Physics Department at Brandeis.

 

My doctoral research was exploring Drug-DNA interactions at single molecule level using optical tweezers under the supervision of Prof. Mark Williams at Northeastern University, Boston. In our studies we have resolved the mystery related to the DNA binding mode  of  the cancer drug  ActinomycinD and have directly measured the kinetics  related to this binding .  We also investigated the threading intercalators that are being developed as new class of potent anticancer drug in collaboration with Prof. Per Lincoln and Dr. Fredrik Westerlund from Chalmers University, Gothenburg, Sweden.

 

E-mail: thaya@brandeis.edu

Phone: 781-736-2378

Office: Kosow 208

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